SUMO-1 human
SIGMA/S0439 - ≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged)
Synonym: Sentrin-1
MDL Number: MFCD03458656
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| mol wt | 38.5 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli (GST-tagged) |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P63165  |
| Application: | SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody. |
| Biochem/physiol Actions: | Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase. |
| Biochem/physiol Actions: | Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA). |
| General description: | Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells. |
| Physical form: | Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |