Synonym: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride
CAS Number: 521984-48-5
Empirical Formula (Hill Notation): C28H27N3O3 · HCl
Molecular Weight: 489.99
MDL Number: MFCD09265258
Linear Formula: C28H27N3O3 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+; |
| InChI key |
CDKIEBFIMCSCBB-CALJPSDSSA-N |
| Quality Level |
100  |
| SMILES string |
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc3c(-c4ccccc4)n(C)c5ncccc35 |
| solubility |
DMSO: >20 mg/mL |
| |
H2O: <2 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells. |
| Biochem/physiol Actions: |
SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 |
| Biochem/physiol Actions: |
Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics. |
| Packaging: |
5 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
