Strychnine

SIGMA/S0532

Synonym: (−)-Strychnine

CAS Number: 57-24-9
Empirical Formula (Hill Notation): C₂₁H₂₂N₂O₂
Molecular Weight: 334.41
EC Number: 200-319-7
MDL Number: MFCD00005941
Linear Formula: C₂₁H₂₂N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S0532-5G	5 g	$32.40 1/EA	Add To Favorites
45-S0532-10G	10 g	$60.30 1/EA	Add To Favorites
45-S0532-25G	25 g	$104.00 1/EA	Add To Favorites
45-S0532-100G	100 g	$290.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S0532-100G

Properties
Descriptions
Safety Info.
Basic Data

InChI	1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
InChI key	QMGVPVSNSZLJIA-FVWCLLPLSA-N
mp	284-286 °C (lit.)
Quality Level	200
SMILES string	[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]
solubility	chloroform: soluble, clear to hazy

Application:	Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.
Application:	Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.
Biochem/physiol Actions:	At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.
Biochem/physiol Actions:	Convulsant; glycine receptor antagonist not associated with the NMDA receptor.
Biochem/physiol Actions:	Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.
General description:	Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.
General description:	Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.
Packaging:	5, 10, 25, 100 g in glass bottle

Symbol	GHS06,GHS09
Signal word	Danger
Hazard statements	H300 + H310 - H410
Precautionary statements	P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310
Hazard Codes	T+,N
Risk Statements	27/28-50/53
Safety Statements	36/37-45-60-61
RIDADR	UN1692 - class 6.1 - PG 1 - Strychnine
WGK Germany	WGK 2

mp	284-286 °C (lit.)
UNSPSC	12352210

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