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SB 239063

SIGMA/S0569 - >98% (HPLC)

Synonym: trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole

CAS Number: 193551-21-2
Empirical Formula (Hill Notation): C20H21N4O2F
Molecular Weight: 368.40
MDL Number: MFCD03792786
Linear Formula: C20H21N4O2F
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S0569-5MG 5 mg
 $237.00
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45-S0569-25MG 25 mg
 $941.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S0569-25MG

 

assay >98% (HPLC)
color white
form powder
InChI 1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-
InChI key ZQUSFAUAYSEREK-WKILWMFISA-N
mp 206-207.2 °C
originator GlaxoSmithKline
Quality Level 100 
SMILES string COc1nccc(n1)-c2c(ncn2[C@@H]3CC[C@@H](O)CC3)-c4ccc(F)cc4
solubility DMSO: 11 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics.
Biochem/physiol Actions: Potent p38 MAP kinase inhibitor. Selective for α and β. No activity against γ and δ isoforms.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung.
Legal Information: Sold for research purposes under agreement from Glaxo­Smith­Kline
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
mp 206-207.2 °C
Storage Temp. 2-8°C
UNSPSC 12352200

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