Anti-Sodium Channel NaV1.5 antibody produced in rabbit
SIGMA/S0819 - affinity isolated antibody, lyophilized powder
Synonym: Anti-SKM2; Anti-Scn5a
MDL Number: MFCD04975341
Product Type: Chemical
Immunohistochemistry Anti-Nav1.5: Cat. No. S0819: Immunohistochemical staining of Nav1.5 in Rat myocardium paraffin-embedded sections using Anti-Nav1.5 antibody, (1:100). Staining is specific for cardiomyocytes while smooth muscles cells in the small vessels are negative (red arrows). Hematoxilin is used as the counterstain.
Immunoblotting Anti-NaV1.5: Cat. No. S0819: Western blot analysis of Rat heart membranes. Lanes 1. Anti-NaV1.5 antibody, (1:200). 2. Anti-NaV1.5 antibody, preincubated with the control peptide antigen.
Immunoblotting Anti-NaV1.5: Cat. No. S0819: Western blot analysis of NaV1.5 in human-NaV1.5 transfected HEK-293 cells. Lanes 1. Anti-NaV1.5 antibody, (1:200). 2. Anti-NaV1.5 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:200 using rat heart membranes |
| UniProt accession no. | P15389  |
| Application: | Anti-Sodium Channel NaV1.5 antibody produced in rabbit has been in immunoblotting and immunofluorescence. |
| Biochem/physiol Actions: | SCN5A (sodium voltage-gated channel α subunit 5) regulates the movement of sodium ions into cells, which helps in the production and diffusion of electrical impulses. SCN5A mutations results in the loss or gain of sodium channel activity and cause several cardiac diseases like Brugada syndrome, Long QT syndrome type 3, Sick sinus syndrome and progressive familial heart block. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | SCN5A (sodium voltage-gated channel α subunit 5) codes for an α subunit of the cardiac sodium channel (NaV1.5). It is located on human chromosome 3p22.2. |
| Immunogen: | peptide corresponding to amino acid residues 493-511 of rH1 (Accession P15389). This epitope is identical in mouse and highly homologous in human (17/19 residues identical). |
| Physical form: | Lyophilized at ~0.8 mg/mL in phosphate buffered, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |