(R)-(+)-SKF-38393 hydrochloride
SIGMA/S101 - ≥98% (HPLC), solid
CAS Number: 81702-42-3
Empirical Formula (Hill Notation): C16H17NO2 · HCl
Molecular Weight: 291.77
MDL Number: MFCD00055189
Linear Formula: C16H17NO2 · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white to light tan |
| form | solid |
| InChI | 1S/C16H17NO2.ClH/c18-15-8 |
| InChI key | YEWHJCLOUYPAOH-PFEQFJNWSA |
| optical activity | [α]22/D +16.1°, c = 1.2 in methanol(lit.) |
| Quality Level | 100  |
| SMILES string | Cl.Oc1cc2CCNC[C@H](c3cccc |
| solubility | 0.1 M HCl: 1.2 mg/mL |
| aqueous base: unstable | |
| ethanol: 3.4 mg/mL | |
| H2O: 5 mg/mL | |
| storage condition | desiccated |
| Application: | (R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6 |
| Biochem/physiol Actions: | (R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a benzazepine derivative, exhibits anorectic effects. |
| Disclaimer: | Light sensitive |
| Features and Benefits: | This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 100 mg in glass bottle |
| Preparation Note: | Solutions may be stored for several days at 4 °C. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |