Streptonigrin from Streptomyces flocculus

SIGMA/S1014 - ≥98%

Synonym: Bruneomycin; Nigrin

CAS Number: 3930-19-6
Empirical Formula (Hill Notation): C₂₅H₂₂N₄O₈
Molecular Weight: 506.46
EC Number: 223-501-8
MDL Number: MFCD00063401
Linear Formula: C₂₅H₂₂N₄O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S1014-1MG	1 mg	$130.00 1/EA	Add To Favorites
45-S1014-5MG	5 mg	$476.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	viruses
assay	≥98%
InChI	1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
InChI key	PVYJZLYGTZKPJE-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O
storage temp.	2-8°C

Biochem/physiol Actions:

Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	53-28-36/37/39-45
RIDADR	UN 3462 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	12352200

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