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Spermine tetrahydrochloride

SIGMA/S1141 - BioReagent, Molecular Biology

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

CAS Number: 306-67-2
Empirical Formula (Hill Notation): C10H26N4 · 4HCl
Molecular Weight: 348.18
EC Number: 206-189-8
MDL Number: MFCD00012914
Linear Formula: C10H26N4 · 4HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S1141-1G 1 g
 $88.90
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45-S1141-5G 5 g
 $312.00
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45-S1141-10G 10 g
 $460.00
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foreign activity DNase, RNase, protease, NICKase, none detected
form solid
grade Molecular Biology
InChI 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key XLDKUDAXZWHPFH-UHFFFAOYSA-N
mp 310-311 °C (dec.) (lit.)
product line BioReagent
Quality Level 300 
SMILES string Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
solubility H2O: soluble 100 mg/mL, clear, colorless to light yellow
storage temp. room temp
Application: Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions: Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Biochem/physiol Actions: Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Biochem/physiol Actions: Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
General description: Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
mp 310-311 °C (dec.) (lit.)
Storage Temp. room temp
UNSPSC 12352116

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