Streptomycin sulfate salt

SIGMA/S1277 - powder, BioXtra, suitable for mouse embryo cell culture

CAS Number: 3810-74-0
Empirical Formula (Hill Notation): C₂₁H₃₉N₇O₁₂ · 1.5H₂O₄S
Molecular Weight: 728.69
EC Number: 223-286-0
MDL Number: MFCD00037023
Linear Formula: C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S1277-50G	50 g	$116.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S1277-50G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
form	powder
InChI	1S/2C21H39N7O12.3H2O4S/c21-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;31-5(2,3)4/h24-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
InChI key	QTENRWWVYAAPBI-YZTFXSNBSA-N
mode of action	protein synthesis \| interferes
potency	≥720 I.U. per mg
product line	BioXtra
Quality Level	200
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
storage temp.	2-8°C
technique(s)	cell culture \| embryo: suitable

Application:	Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Biochem/physiol Actions:	Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation. Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin. Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
Disclaimer:	Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.
General description:	Chemical structure: aminoglycoside
Packaging:	5, 50 g in poly bottle
Preparation Note:	Stock solutions should be prepared with sterile water at concentrations between 20-25 mg/ml.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H361fd
Precautionary statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	63-22
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352207

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