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STO-609-acetic acid

SIGMA/S1318 - ≥95% (HPLC), solid

Synonym: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid - acetic acid

CAS Number: 1173022-21-3
Empirical Formula (Hill Notation): C19H10N2O3 · C2H4O2
Molecular Weight: 374.35
MDL Number: MFCD06411456
Linear Formula: C19H10N2O3 · C2H4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S1318-5MG 5 mg
 $210.00
1/EA		 Add To Favorites
45-S1318-25MG 25 mg
 $562.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
form solid
InChI 1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChI key WNRSTFUVBWNELX-UHFFFAOYSA-N
mp >300 °C
Quality Level 100 
SMILES string CC(O)=O.OC(=O)c1ccc2-c3nc4ccccc4n3C(=O)c5cccc1c25
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: STO609 has been used as a calcium/calmodulin-dependent protein kinase kinase (CAMKK) inhibitor in mouse MLL-AF9 acute myeloid leukemia (AML) cells.
Biochem/physiol Actions: Selective Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist.
Biochem/physiol Actions: Selective Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist. Inhibits CamKKa and CaMKKb with Ki = 80 and 15 ng/mL, respectively. Does not inhibit downstream CaM kinases (CaMKI and CaMKIV).
Features and Benefits: This compound is featured on the Ca/CaMKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: 1:1 adduct with acetic acid
General description: STO-609 reduces tumorigenicity of liver cancer cells in vivo. TO-609 reduces the activation of AMP (adenosine monophosphate)-activated protein kinase (AMPK) by ionomycin in a dose dependant manner.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
mp >300 °C
Storage Temp. 2-8°C
UNSPSC 12352106

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