SB−3CT
SIGMA/S1326 - ≥98% (HPLC), powder
Synonym: 2-
CAS Number: 292605-14-2
Empirical Formula (Hill Notation): C15H14O3S2
Molecular Weight: 306.40
MDL Number: MFCD09836266
Linear Formula: C15H14O3S2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C15H14O3S2/c16-20(17,1 |
| InChI key | LSONWRHLFZYHIN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=S(=O)(CC1CS1)c2ccc(Oc3c |
| solubility | DMSO: >20 mg/mL |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | SB−3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation. |
| Biochem/physiol Actions: | SB−3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. |
| Biochem/physiol Actions: | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM). |
| Legal Information: | Sold under license of U.S. Patent 6,703,415. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |