Synonym: (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; (±)-SKF-81297 hydrobromide
CAS Number: 71636-61-8
Empirical Formula (Hill Notation): C16H16ClNO2 · HBr
Molecular Weight: 370.67
MDL Number: MFCD00153782
Linear Formula: C16H16ClNO2 · HBr
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to light tan |
| form |
solid |
| InChI |
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H |
| InChI key |
RMIJGBMRNYUZRG-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3 |
| solubility |
DMSO: >10 mg/mL |
| |
ethanol: 6.3 mg/mL |
| |
H2O: 1.7 mg/mL |
| storage condition |
desiccated |
| Application: |
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats. |
| Biochem/physiol Actions: |
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist. |
| Disclaimer: |
Product is air and light sensitive |
| Packaging: |
25, 100 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |
GHS07