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(±)-6-Chloro-PB hydrobromide

SIGMA/S143 - ≥98% (HPLC), solid

Synonym: (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; (±)-SKF-81297 hydrobromide

CAS Number: 71636-61-8
Empirical Formula (Hill Notation): C16H16ClNO2 · HBr
Molecular Weight: 370.67
MDL Number: MFCD00153782
Linear Formula: C16H16ClNO2 · HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S143-25MG 25 mg
 $279.00
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assay ≥98% (HPLC)
color white to light tan
form solid
InChI 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
InChI key RMIJGBMRNYUZRG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3
solubility DMSO: >10 mg/mL
  ethanol: 6.3 mg/mL
  H2O: 1.7 mg/mL
storage condition desiccated
Application: (±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.
Biochem/physiol Actions: (+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
Disclaimer: Product is air and light sensitive
Packaging: 25, 100 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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