Anti-Substance P antibody produced in rabbit
SIGMA/S1542 - whole antiserum
Synonym: Anti-SP
MDL Number: MFCD00162870
Product Type: Chemical
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| antibody form | whole antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| contains | 15 mM sodium azide |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | human, pig, bovine, rat, cat, monkey |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | dot blot: 1:20,000 |
| radioimmunoassay: 1:5,000 | |
| UniProt accession no. | P20366  |
| Analysis Note: | The antiserum is evaluated for activity and specificity by dot blot immunoassay and RIA. |
| Application: | Anti-Substance P antibody has been used in immunostaining and immunohistochemistry. |
| Biochem/physiol Actions: | Substance P (SP) improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, trigger glandular secretion and controls autonomic reflexes. It plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer. |
| Biochem/physiol Actions: | Substance P (SP) is a neurotransmitter or neuromodulator. SP mediates the process of neurogenic inflammation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Substance P (SP) is a 11 amino acid peptide. It is a member of tachykinins family, that includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1 It is located on human chromosome 7q21.3. |
| General description: | Substance P (SP) is widely distributed throughout the central nervous system (CNS) and peripheral nervous system, including the brain, spinal cord, primary sensory neurons and intrinsic nerve fibers associated with the gastrointestinal (GI) tract. |
| Immunogen: | synthetic Substance P (SP), conugated to KLH. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |