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R(+)-SKF-81297 hydrobromide

SIGMA/S179 - ≥98% (HPLC), solid

Synonym: R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

CAS Number: 253446-15-0
Empirical Formula (Hill Notation): C16H16ClNO2 · HBr
Molecular Weight: 370.67
MDL Number: MFCD00671792
Linear Formula: C16H16ClNO2 · HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S179-5MG 5 mg
 $863.00
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assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
InChI key RMIJGBMRNYUZRG-BTQNPOSSSA-N
optical activity [α]22/D +15.14°, c = 0.52 in DMF(lit.)
Quality Level 100 
SMILES string Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
solubility DMSO: soluble
  H2O: 6 mg/mL
storage condition desiccated
  protect from light
Application: R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
• to test it effect on the spike firing in rat retinal ganglion cells
• in human embryonic kidney (HEK) 293T cells
• to test its inhibitory effect in microglial cells
Biochem/physiol Actions: SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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