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S32826 disodium salt hydrate

SIGMA/S1825 - ≥98% (HPLC)

Synonym: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt hydrate

CAS Number: 1096770-84-1 (free acid)
Empirical Formula (Hill Notation): C21H34NNa2O4P · xH2O
Molecular Weight: 441.45 (anhydrous basis)
MDL Number: MFCD12912442
Linear Formula: C21H34NNa2O4P · xH2O
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-S1825-5MG 5 mg
$191.00
1/EA
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45-S1825-25MG 25 mg
$737.00
1/EA
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C21H36NO4P.2Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26;;/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2
InChI key DGRFALMFDGBLCP-UHFFFAOYSA-L
Quality Level 100 
SMILES string [Na+].[Na+].CCCCCCCCCCCCCC(=O)Nc1ccc(CP([O-])([O-])=O)cc1
solubility H2O: ≥10 mg/mL
storage condition desiccated
storage temp. −20°C
Application: S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phosphatidic acid (LPA) formation. S32826 may be used to help determine the role of ATX in malignant cell processes such as tumorigenesis, invasion, and metastases; cardia bifida and atherosclerosis.
Biochem/physiol Actions: S32826 is a potent inhibitor of autotaxin.
Biochem/physiol Actions: S32826 is a potent inhibitor of autotaxin. Autotaxin is a newly discovered lyso-phospholipase D (lysoPLD). Autotaxin and lyso-phosphatidic acid (LPA) have been associated with early cancer progression and motility of cancer cells as well as with metastasis. Because of localization (adipose tissue), the enzyme might play an important role in diabetes and obesity. Autotaxin might be the only source of LPA. S32826 is the strongest inhibitor of autotaxin reported. The compound shows activity in cellular or ex vivo models.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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