S32826 disodium salt hydrate
SIGMA/S1825 - ≥98% (HPLC)
Synonym: [4-
CAS Number: 1096770-84-1 (free acid)
Empirical Formula (Hill Notation): C21H34NNa2O4P · xH2O
Molecular Weight: 441.45 (anhydrous basis)
MDL Number: MFCD12912442
Linear Formula: C21H34NNa2O4P · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C21H36NO4P.2Na/c1-2-3- |
| InChI key | DGRFALMFDGBLCP-UHFFFAOYSA |
| Quality Level | 100 ![]() |
| SMILES string | [Na+].[Na+].CCCCCCCCCCCCC |
| solubility | H2O: ≥10 mg/mL |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phosphatidic acid (LPA) formation. S32826 may be used to help determine the role of ATX in malignant cell processes such as tumorigenesis, invasion, and metastases; cardia bifida and atherosclerosis. |
| Biochem/physiol Actions: | S32826 is a potent inhibitor of autotaxin. |
| Biochem/physiol Actions: | S32826 is a potent inhibitor of autotaxin. Autotaxin is a newly discovered lyso-phospholipase D (lysoPLD). Autotaxin and lyso-phosphatidic acid (LPA) have been associated with early cancer progression and motility of cancer cells as well as with metastasis. Because of localization (adipose tissue), the enzyme might play an important role in diabetes and obesity. Autotaxin might be the only source of LPA. S32826 is the strongest inhibitor of autotaxin reported. The compound shows activity in cellular or ex vivo models. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |

