Anti-Synapsin I antibody produced in rabbit
SIGMA/S193 - affinity isolated antibody, lyophilized powder
Synonym: Anti-EPILX; Anti-MRX50; Anti-SYN1a; Anti-SYN1b; Anti-SYNI
MDL Number: MFCD00282157
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| mol wt | antigen ~80 kDa (Synapsin Ia) |
| Quality Level | 100  |
| species reactivity | rat, mouse, human, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | dot blot: 1:1000 |
| immunohistochemistry (frozen sections): 1:2000 | |
| immunoprecipitation (IP): 1 μg | |
| indirect immunofluorescence: 1:2000 | |
| western blot: 1:1000 | |
| UniProt accession no. | P17600  |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. • Western Blotting (1 paper) • immunohistochemistry • immunoblotting • immunoprecipitation • ELISA. Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals. |
| Biochem/physiol Actions: | Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23. |
| Immunogen: | synapsin I from bovine brain. |
| Packaging: | 10 μg in poly bottle |
| Physical form: | Lyophilized from ammonium bicarbonate (5 mM) |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |