STX64

SIGMA/S1950 - ≥98% (HPLC)

Synonym: 667 Coumate; BN 83495

CAS Number: 288628-05-7
Empirical Formula (Hill Notation): C₁₄H₁₅NO₅S
Molecular Weight: 309.34
MDL Number: MFCD12912443
Linear Formula: C₁₄H₁₅NO₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S1950-5MG	5 mg	$233.00 1/EA		Add To Favorites
45-S1950-25MG	25 mg	$620.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChI key	DSLPMJSGSBLWRE-UHFFFAOYSA-N
SMILES string	NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1
solubility	DMSO: >20 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	STX64 is a potent, irreversible inhibitor of steroid sulfatase.
Biochem/physiol Actions:	STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC₅₀ = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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