Anti-Sodium Channel NaV1.8 antibody produced in rabbit
SIGMA/S2071 - affinity isolated antibody, lyophilized powder
Synonym: Anti-PN3; Anti-SCN10A
MDL Number: MFCD08705520
Product Type: Chemical
Immunohistochemistry Anti-Nav1.8: Cat. No. S2071: Immunohistochemical staining of adult Rat dorsal root ganglion (DRG) using Anti-Nav1.8 antibody. Nav1.8 staining (red) is cytoplasmic and the intensity varies among DRG cells. There is a partial overlap in the distribution of Nav1.8 and neurofilament 200 (green).
Immunoblotting Anti-NaV1.8: Cat. No. S2071: Western blot analysis of Rat DRG lysates. Lanes 1. Anti-NaV1.8 antibody, (1:200). 2. Anti-NaV1.8 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (frozen sections): suitable using adult rat DRG |
| western blot: 1:200 using rat DRG lysates | |
| UniProt accession no. | Q62968  |
| Application: | Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry. |
| Biochem/physiol Actions: | Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Anti-Sodium Channel NaV1.8 specifically recognizes NaV1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the |
| General description: | Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2. |
| Immunogen: | peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Nav1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide. |
| Hazard Codes | Xn |
| Risk Statements | 21/22 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |