Anti-Sodium Channel NaV1.9 antibody produced in rabbit
SIGMA/S2196 - affinity isolated antibody, lyophilized powder
Synonym: Anti-NAN; Anti-SNS2
MDL Number: MFCD08705521
Product Type: Chemical
Immunohistochemistry Anti-Nav1.9: Cat. No. S2196: Immunohistochemical staining of formalin frozen Rat embryo dorsal root ganglion (DRG) sections with Anti-Nav1.9 antibody. (A) Cells within the DRG were stained (see solid line frame enlarged in B) as well as fibers and the area of entry of dorsal root into the spinal cord (see dashed line frame enlarged in C). DAPI is used as the counterstain.
Immunoblotting Anti-NaV1.9: Cat. No. S2196: Western blot analysis of Rat DRG lysates. Lanes 1. Anti-NaV1.9 antibody, (1:200). 2. Anti-NaV1.9 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:200 using rat DRG lysates |
| UniProt accession no. | O88457  |
| Biochem/physiol Actions: | Sodium Channel NaV1.9 participates in pain at the time of inflammation. Downregulation of Nav1.9 is observed in Hirschsprung′s disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Sodium Channel NaV1.9 is a threshold channel, that is expressed in dorsal root ganglion neurons , peripheral nociceptive neurons and visceral afferents. It is also called as SNS and NaN. It is encoded by SCN11A (sodium voltage-gated channel subunit 11) and is located on human chromosome 3p22. |
| Immunogen: | peptide CNGDLSSLDVAKVKVHND corresponding to residues 1748-1765 of rat Nav1.9. This sequence has 15/18 residues identical in mouse and 14/18 residues identical in human. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |