Spermidine
SIGMA/S2626 - ≥99% (GC)
Synonym: 1,8-
CAS Number: 124-20-9
Empirical Formula (Hill Notation): C7H19N3
Molecular Weight: 145.25
EC Number: 204-689-0
MDL Number: MFCD00008229
Linear Formula: NH2(CH2)3NH(CH2)4NH2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S2626-5G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S2626-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S2626-1G
| assay | ≥99% (GC) |
| biological source | synthetic |
| density | 0.925 g/mL at 25 °C (lit.) |
| form | solid or liquid (clear) |
| impurities | DNase, none detected |
| protease, none detected | |
| RNase, none detected | |
| InChI | 1S/C7H19N3/c8-4-1-2-6-10- |
| InChI key | ATHGHQPFGPMSJY-UHFFFAOYSA |
| mp | 22-25 °C |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | NCCCCNCCCN |
| solubility | water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow |
| storage temp. | room temp |
| Application: | Spermidine has been used: • in the preparation of 5x transcription buffer • in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes • as a standard in the analytical study of rat brain polyamines (185) |
| Biochem/physiol Actions: | Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity. |
| Biochem/physiol Actions: | Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity. |
| Disclaimer: | Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently. |
| General description: | Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources. |
| General description: | The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide. |
| Other Notes: | Store under inert gas. Air sensitive; strongly hygroscopic. |
| Packaging: | 1, 5, 25 g in glass bottle |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3259PSN2 8 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 233.6 °F - closed cup |
| Flash Point(C) | 112 °C - closed cup |
| Purity | ≥99% (GC) |
| mp | 22-25 °C |
| Density | 0.925 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |