Suramin sodium salt

SIGMA/S2671 - ≥98% (HPLC)

Synonym: Suramine sodium salt

CAS Number: 129-46-4
Empirical Formula (Hill Notation): C₅₁H₃₄N₆Na₆O₂₃S₆
Molecular Weight: 1429.17
EC Number: 204-949-3
MDL Number: MFCD00210217
Linear Formula: C₅₁H₃₄N₆Na₆O₂₃S₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S2671-25MG	25 mg	$120.00 1/EA		Add To Favorites
45-S2671-100MG	100 mg	$354.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
impurities	<15% water (Karl Fischer)
InChI	1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChI key	VAPNKLKDKUDFHK-UHFFFAOYSA-H
Quality Level	200
SMILES string	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
solubility	H₂O: >10 mg/mL

Application:	Suramin sodium salt has been used: • as a potent blocker of rat P2Y₂ purinergic receptor • to study its effects on short circuit current (I_sc) across strial marginal cells • to show its effects on initial burst of glial activity • to assess its neuroprotective potential in rats • as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP)
Biochem/physiol Actions:	Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.
General description:	Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria, paresthesias, vomiting and neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.
Other Notes:	To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	100, 500 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352201

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