Synonym: 6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
CAS Number: 80751-85-5
Empirical Formula (Hill Notation): C18H20NClO2 · HBr
Molecular Weight: 398.72
MDL Number: MFCD03792727
Linear Formula: C18H20NClO2 · HBr
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
solid |
| InChI |
1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H |
| InChI key |
FHYWNBUFNGHNCP-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3 |
| solubility |
DMSO: >20 mg/mL |
| |
H2O: insoluble |
| Application: |
SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice. |
| Biochem/physiol Actions: |
D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo. |
| Biochem/physiol Actions: |
SKF-83959 is an atypical agonist of D1 dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D1 receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D1 receptors coupled to adenylyl cyclase. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |
