Spermine tetrahydrochloride
SIGMA/S2876 - powder or crystals
Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
CAS Number: 306-67-2
Empirical Formula (Hill Notation): C10H26N4 · 4HCl
Molecular Weight: 348.18
EC Number: 206-189-8
MDL Number: MFCD00012914
Linear Formula: C10H26N4 · 4HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S2876-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S2876-100G
| form | powder or crystals |
| InChI | 1S/C10H26N4.4ClH/c11-5-3- |
| InChI key | XLDKUDAXZWHPFH-UHFFFAOYSA |
| mp | 310-311 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | Cl.Cl.Cl.Cl.NCCCNCCCCNCCC |
| solubility | water, high purity: 100 mg/ml |
| storage temp. | room temp |
| Application: | Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken. |
| Application: | Used to precipitate DNA from low salt aqueous buffers. |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Biochem/physiol Actions: | Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger. In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins. |
| Preparation Note: | Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 310-311 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |