Sodium salicylate
SIGMA/S3007 - ReagentPlus®, ≥99.5% (titration)
Synonym: 2-Hydroxybenzoic acid sodium salt; Salicylic acid sodium salt; Sodium 2-hydroxybenzoate
CAS Number: 54-21-7
Empirical Formula (Hill Notation): C7H5NaO3
Molecular Weight: 160.10
EC Number: 200-198-0
MDL Number: MFCD00002440
Linear Formula: HOC6H4COONa
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: S3007-500G
This image depicts SKU: S3007-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: S3007-1KG
This image depicts SKU: S3007-1KG
| assay | ≥99.5% (titration) |
| color | white |
| form | crystalline |
| InChI | 1S/C7H6O3.Na/c8-6-4-2-1-3 |
| InChI key | ABBQHOQBGMUPJH-UHFFFAOYSA |
| mp | >300 °C (lit.) |
| product line | ReagentPlus® |
| Quality Level | 200  |
| SMILES string | [Na+].Oc1ccccc1C([O-])=O |
| solubility | water: 575.7 g/L at 25 °C (77 °F) |
| useful pH range | 6.85 (26.3 °C) |
| Application: | Sodium salicylate has been used: • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential. • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats. • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique. |
| General description: | Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Ji |
| Legal Information: | ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 100, 500 g in poly bottle |
| Packaging: | 5 kg in poly drum |
| Symbol |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302 - H319 - H361d |
| Precautionary statements | P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 208.9 °F - Pensky-Martens c |
| Flash Point(C) | 98.3 °C - Pensky-Martens cl |
| Purity | ≥99.5% (titration) |
| mp | >300 °C (lit.) |
| UNSPSC | 12352302 |