SC 19220
SIGMA/S3065 - ≥98% (HPLC), solid
Synonym: 2-Acetylhydrazide 10(11H)-carboxylic acid; 8-
CAS Number: 19395-87-0
Empirical Formula (Hill Notation): C16H14N3O3Cl
Molecular Weight: 331.75
MDL Number: MFCD02259329
Linear Formula: C16H14N3O3Cl
Product Type: Chemical
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This image depicts S3065-10MG.
This image depicts S3065-10MG.
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C16H14ClN3O3/c1-10(21) |
| InChI key | KNURFLJTOUGOOQ-UHFFFAOYSA |
| mp | 190-191 °C (lit.) |
| Quality Level | 100  |
| SMILES string | CC(=O)NNC(=O)N1Cc2ccccc2O |
| solubility | DMSO: soluble 10 mg/mL |
| H2O: insoluble |
| Application: | SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures. |
| Biochem/physiol Actions: | EP1 Prostanoid receptor antagonist |
| Biochem/physiol Actions: | SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 190-191 °C (lit.) |
| UNSPSC | 12352200 |