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SC 19220

SIGMA/S3065 - ≥98% (HPLC), solid

Synonym: 2-Acetylhydrazide 10(11H)-carboxylic acid; 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

CAS Number: 19395-87-0
Empirical Formula (Hill Notation): C16H14N3O3Cl
Molecular Weight: 331.75
MDL Number: MFCD02259329
Linear Formula: C16H14N3O3Cl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S3065-10MG 10 mg
 $193.00
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assay ≥98% (HPLC)
color white
form solid
InChI 1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
InChI key KNURFLJTOUGOOQ-UHFFFAOYSA-N
mp 190-191 °C (lit.)
Quality Level 100 
SMILES string CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13
solubility DMSO: soluble 10 mg/mL
  H2O: insoluble
Application: SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.
Biochem/physiol Actions: EP1 Prostanoid receptor antagonist
Biochem/physiol Actions: SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 190-191 °C (lit.)
UNSPSC 12352200

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