Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
SIGMA/S3134 - lyophilized powder, ≥2,000 units/mg solid
Synonym: Streptokinase from Streptococcus hemolyticus
CAS Number: 9002-01-1
EC Number: 232-647-1
MDL Number: MFCD00082037
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S3134-250KU
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S3134-50KU
| form | lyophilized powder |
| InChI | 1S/C11H19NO2/c13-11(14)10 |
| InChI key | XRZWVSXEDRYQGC-UHFFFAOYSA |
| Quality Level | 200  |
| shipped in | wet ice |
| SMILES string | N1C(CC(C1)C2CCCCC2)C(=O)O |
| specific activity | ≥2,000 units/mg solid |
| storage temp. | −20°C |
| Application: | Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients. |
| Application: | Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare. |
| Biochem/physiol Actions: | Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare. |
| General description: | Research area: Cell signaling Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains. |
| Other Notes: | One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial. |
| Packaging: | 10000, 50000, 250000 units in glass bottle |
| Physical form: | Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥2,000 units/mg solid |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 3.4.99.0 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |