Advanced Search



Spironolactone

SIGMA/S3378 - 97.0-103.0%

Synonym: 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate; 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

CAS Number: 52-01-7
Empirical Formula (Hill Notation): C24H32O4S
Molecular Weight: 416.57
EC Number: 200-133-6
MDL Number: MFCD00082250
Linear Formula: C24H32O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S3378-1G 1 g
 $93.30
1/EA		 Add To Favorites
45-S3378-5G 5 g
 $323.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S3378-1G

 

assay 97.0-103.0%
InChI 1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChI key LXMSZDCAJNLERA-ZHYRCANASA-N
mp 207-208 °C (lit.)
Quality Level 200 
SMILES string CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
solubility chloroform: complete 50 mg/ml, clear, faintly yellow
Application: Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.
Biochem/physiol Actions: Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.
Biochem/physiol Actions: Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis. It reduces hypertension, improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure. Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1, 5 g in glass bottle
Preparation Note: Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.
Purity 97.0-103.0%
mp 207-208 °C (lit.)
UNSPSC 51111800

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top