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SB 216763

SIGMA/S3442 - >98% (HPLC)

Synonym: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS Number: 280744-09-4
Empirical Formula (Hill Notation): C19H12N2O2Cl2
Molecular Weight: 371.22
MDL Number: MFCD09753369
Linear Formula: C19H12N2O2Cl2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S3442-5MG 5 mg
 $205.00
1/EA		 Add To Favorites
45-S3442-25MG 25 mg
 $780.00
1/EA		 Add To Favorites

 

assay >98% (HPLC)
color orange
InChI 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChI key JCSGFHVFHSKIJH-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
solubility DMSO: soluble 20 mg/mL
  H2O: insoluble
storage temp. −20°C
Application: SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.
Biochem/physiol Actions: Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.
Biochem/physiol Actions: SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GSK-3  and PKB/Akt  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information: Sold for research purposes under agreement from Glaxo­Smith­Kline
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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