SM-19712 hydrate

SIGMA/S3445 - ≥98% (HPLC)

Synonym: 4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate

CAS Number: 194542-56-8 (anhydrous)
Empirical Formula (Hill Notation): C₁₈H₁₃ClN₅NaO₃S · xH₂O
Molecular Weight: 437.84 (anhydrous basis)
MDL Number: MFCD06798351
Linear Formula: C₁₈H₁₃ClN₅NaO₃S · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S3445-5MG	5 mg	$259.00 1/EA	Add To Favorites
45-S3445-25MG	25 mg	$958.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to light brown
form	powder
InChI	1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1
InChI key	HLHPDQXMLDUDQV-UHFFFAOYSA-M
Quality Level	100
SMILES string	ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1
solubility	DMSO: ≥20 mg/mL
	H₂O: ≥20 mg/mL
storage temp.	2-8°C

Application:	SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.
Biochem/physiol Actions:	Nonpeptide, potent and selective endothelin converting enzyme inhibitor.
Biochem/physiol Actions:	SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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