SEW2871
SIGMA/S3944 - ≥98% (HPLC), solid
Synonym: 5-
CAS Number: 256414-75-2
Empirical Formula (Hill Notation): C20H10F6N2OS
Molecular Weight: 440.36
MDL Number: MFCD00096600
Linear Formula: C20H10F6N2OS
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C20H10F6N2OS/c21-19(22 |
| InChI key | OYMNPJXKQVTQTR-UHFFFAOYSA |
| mp | 94.5-95.3 °C |
| Quality Level | 100  |
| SMILES string | FC(F)(F)c1cccc(c1)-c2noc( |
| solubility | DMSO: ≥10 mg/mL |
| H2O: insoluble | |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Application: | SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice. |
| Application: | SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3. |
| Biochem/physiol Actions: | Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist. |
| Biochem/physiol Actions: | SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia. |
| Features and Benefits: | This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 1, 5 mg in glass bottle |
| Packaging: | Light sensitive. |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| mp | 94.5-95.3 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352211 |