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Splitomicin

SIGMA/S4068 - ≥98% (HPLC), powder

Synonym: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

CAS Number: 5690-03-9
Empirical Formula (Hill Notation): C13H10O2
Molecular Weight: 198.22
MDL Number: MFCD08705254
Linear Formula: C13H10O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4068-5MG 5 mg
 $95.30
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assay ≥98% (HPLC)
form powder
InChI 1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
InChI key ISFPDBUKMJDAJH-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1CCc2c(O1)ccc3ccccc23
storage temp. 2-8°C
Application: Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells and sirtuins in human breast cancer cells. Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.
Biochem/physiol Actions: Sir2p (silent information regulator) and HDAC inhibitor.
Biochem/physiol Actions: Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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