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SL327

SIGMA/S4069 - ≥98% (HPLC), Mixture of E & Z isomers, solid

Synonym: α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile; SL 327; SL-327

CAS Number: 305350-87-2
Empirical Formula (Hill Notation): C16H12F3N3S
Molecular Weight: 335.35
MDL Number: MFCD06411432
Linear Formula: C16H12F3N3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4069-5MG 5 mg
 $178.00
1/EA		 Add To Favorites
45-S4069-25MG 25 mg
 $646.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChI key JLOXTZFYJNCPIS-FYWRMAATSA-N
mp 127-128.2 °C
Quality Level 100 
SMILES string NC(Sc1ccc(N)cc1)=C(C#N)c2ccccc2C(F)(F)F
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage condition desiccated
  protect from light
storage temp. 2-8°C
Application: SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).
Application: SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
Biochem/physiol Actions: SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.
Biochem/physiol Actions: SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 127-128.2 °C
Storage Temp. 2-8°C
UNSPSC 12352200

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