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SR 12813

SIGMA/S4194 - ≥98%, solid

Synonym: Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate

CAS Number: 126411-39-0
Empirical Formula (Hill Notation): C24H42O7P2
Molecular Weight: 504.53
MDL Number: MFCD00888473
Linear Formula: C24H42O7P2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4194-1MG 1 mg
 $57.60
1/EA		 Add To Favorites
45-S4194-5MG 5 mg
 $192.00
1/EA		 Add To Favorites

 

assay ≥98%
biological source synthetic (organic)
form solid
InChI 1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3
InChI key YQLJDECYQDRSBI-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string CCOP(=O)(OCC)C(=C/c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)P(=O)(OCC)OCC
solubility DMSO: ≥10 mg/mL
  H2O: insoluble
Application: SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.
Biochem/physiol Actions: SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor.
Biochem/physiol Actions: SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
UNSPSC 12352203

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