SB-277011-A hydrochloride hydrate

SIGMA/S4326 - ≥98% (HPLC)

CAS Number: 215804-67-4 (anhydrous)
Empirical Formula (Hill Notation): C₂₈H₃₀N₄O · HCl · xH₂O
Molecular Weight: 475.02 (anhydrous basis)
MDL Number: MFCD16875431
Linear Formula: C₂₈H₃₀N₄O · HCl · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S4326-5MG	5 mg	$186.00 1/EA		Add To Favorites
45-S4326-25MG	25 mg	$509.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C28H30N4O.ClH.H2O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);1H;1H2/t20-,24-;;
InChI key	OOWNBQACGIKNGM-ONAIBGCWSA-N
originator	GlaxoSmithKline
Quality Level	100
SMILES string	O.Cl.O=C(N[C@@H]1CC[C@H](CC1)CCN2CCc3cc(ccc3C2)C#N)c4ccnc5ccccc45
solubility	DMSO: 2 mg/mL, clear (warmed)
storage condition	protect from light
storage temp.	2-8°C

Application:	SB-277011-A hydrochloride hydrate has been used: • as a dopamine D3 receptor-selective antagonist in rats to test its effect on 4-propyl-9-hydroxynaphthoxazine ([3H]-(+)-PHNO) radiotracer in cerebellum L9/10 and striatum • as an acetylcholine inhibitor to test its negative allosteric modulation on Ascaris suum nicotinic acetylcholine receptor (Asu-ACR-16) expressed in Xenopus oocytes and its inhibitory effect on locomotion in Caenorhabditis elegans • to test its effect on alcohol consumption in mice
Application:	SB-277011-A hydrochloride hydrate may be used in D3 dopamine receptor-mediated cell signaling studies.
Biochem/physiol Actions:	SB-277011-A is a potent, selective brain-penetrant D3 dopamine receptor antagonist; 80-100x selective for D3 over D2; pKi = 7.95 for hD3 receptor.
Biochem/physiol Actions:	SB-277011-A is the most selective D3 dopamine receptor antagonist.
Biochem/physiol Actions:	The D₃ dopamine receptor antagonist, SB-277011-A inhibits the cocaine-seeking behavior and cocaine-enhances brain stimulation reward in in rats. It decreases drug-seeking behavior and may be useful in treatment of cocaine and methamphetamine addiction.
Features and Benefits:	This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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