SCH-28080
SIGMA/S4443 - ≥98% (HPLC), solid
Synonym: 2-
CAS Number: 76081-98-6
Empirical Formula (Hill Notation): C17H15N3O
Molecular Weight: 277.32
MDL Number: MFCD00834620
Linear Formula: C17H15N3O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to light tan |
| compatibility | for use with ABI 7700 |
| form | solid |
| InChI | 1S/C17H15N3O/c1-13-15(9-1 |
| InChI key | PYKJFEPAUKAXNN-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1nc2c(OCc3ccccc3)cccn2c |
| solubility | DMSO: soluble >10 mg/mL |
| H2O: insoluble | |
| storage temp. | −20°C |
| Application: | SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development. |
| Biochem/physiol Actions: | SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase. |
| Biochem/physiol Actions: | SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |