α-Synuclein E46K human
SIGMA/S4447 - recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder
Synonym: NACP (Non-a-beta component of Alzheimer disease amyloid, precursor); PARK1; PARK4; PD1; non A4 component of amyloid precursor
Product Type: Chemical
SDS-PAGE α-Synuclein E46K human (Cat. No. S4447) was assessed on SDS-PAGE.
| assay | ≥90% (SDS-PAGE) |
| compatibility | for use with ABI StepOnePlus |
| form | lyophilized powder |
| mol wt | apparent mol wt 19-20 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −20°C |
| UniProt accession no. | P37840  |
| Biochem/physiol Actions: | Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A transition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein. |
| Biochem/physiol Actions: | Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |