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DL-Serine hydroxamate

SIGMA/S4503 - seryl-tRNA synthetase inhibitor

Synonym: SHX

CAS Number: 55779-32-3
Empirical Formula (Hill Notation): C3H8N2O3
Molecular Weight: 120.11
MDL Number: MFCD00055712
Linear Formula: C3H8N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4503-250MG 250 mg
 $583.00
1/EA		 Add To Favorites
45-S4503-1G 1 g
 $2010.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: S4503-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: S4503-250MG

 

application(s) cell analysis
assay ≥97% (TLC)
color white to off-white
form powder
InChI 1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
InChI key LELJBJGDDGUFRP-UHFFFAOYSA-N
Quality Level 200 
SMILES string NC(CO)C(=O)NO
storage temp. −20°C
technique(s) ligand binding assay: suitable
Application: Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.
Biochem/physiol Actions: Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.
Packaging: 1 g in poly bottle
Packaging: 250 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (TLC)
Storage Temp. −20°C
UNSPSC 12352209

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