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β-Secretase inhibitor

SIGMA/S4562 - ≥97% (HPLC), powder

Empirical Formula (Hill Notation): C73H118N16O27
Molecular Weight: 1651.81
MDL Number: MFCD02683580
Linear Formula: C73H118N16O27
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4562-1MG 1 mg
 $661.00
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assay ≥97% (HPLC)
biological source synthetic (organic)
color white
form powder
InChI 1S/C73H118N16O27/c1-11-37(8)59(88-66(108)45(23-27-56(101)102)79-63(105)43(21-25-54(97)98)81-72(114)60(39(10)91)89-62(104)41(75)19-15-16-28-74)71(113)85-49(33-90)68(110)80-44(22-26-55(99)100)65(107)87-58(36(6)7)70(112)83-47(31-51(76)93)67(109)82-46(29-34(2
InChI key CQTBDEGWLSDJEP-JMAXQNTPSA-N
mol wt ~_1.65 kDa
mp 200 °C
Quality Level 200 
shipped in dry ice
SMILES string N([C@H]([C@@H](O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CC(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@H](O)C)CCC(=O)O)C
solubility DMSO: soluble
storage temp. −20°C
Amino Acid Sequence: Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe
Application: β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay.(2)
Application: β-Secretase inhibitor may be used to inhibit BACE1 in studies related to AD.
Biochem/physiol Actions: β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is a β-secretase that initiates the production of amyloid protein in Alzheimer′s dieases (AD) patients. β-Secretase inhibitors decrease the generation of β amyloid and formation of amyloid plaques typical of AD.
General description: β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1), an aspartic protease belongs to the protease family of enzymes comprises of six luminal cysteine residues. These residues help in the formation of three intermolecular disulfide bonds and N-linked glycosylation sites.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
mp 200 °C
Storage Temp. −20°C
UNSPSC 12352200

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