Synonym: 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
CAS Number: 160098-96-4
Empirical Formula (Hill Notation): C18H15N7O
Molecular Weight: 345.36
MDL Number: MFCD00933778
Linear Formula: C18H15N7O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
off-white |
| form |
solid |
| InChI |
1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22) |
| InChI key |
UTLPKQYUXOEJIL-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5 |
| solubility |
DMSO: soluble >10 mg/mL |
| |
H2O: insoluble |
| Application: |
SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.4 |
| Biochem/physiol Actions: |
A2A adenosine receptor antagonist. |
| Biochem/physiol Actions: |
SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease. |
| Features and Benefits: |
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |
