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SANT-1

SIGMA/S4572 - ≥98% (HPLC), powder

Synonym: (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine

CAS Number: 304909-07-7
Empirical Formula (Hill Notation): C23H27N5
Molecular Weight: 373.49
MDL Number: MFCD01827306
Linear Formula: C23H27N5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4572-5MG 5 mg
 $209.00
1/EA		 Add To Favorites
45-S4572-25MG 25 mg
 $898.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S4572-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S4572-5MG

 

assay ≥98% (HPLC)
form powder
InChI 1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
InChI key FOORCIAZMIWALX-JJIBRWJFSA-N
Quality Level 100 
SMILES string Cc1nn(-c2ccccc2)c(C)c1C=NN3CCN(CC3)Cc4ccccc4
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Application: • SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling
• in the generation of functional human pancreatic β cells in vitro
• to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death
Biochem/physiol Actions: SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
Biochem/physiol Actions: SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist.
Biochem/physiol Actions: SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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