SMIFH2
SIGMA/S4826 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 340316-62-3
Empirical Formula (Hill Notation): C15H9BrN2O3S
Molecular Weight: 377.21
Linear Formula: C15H9BrN2O3S
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | light yellow to yellow-green |
| form | powder |
| InChI | 1S/C15H9BrN2O3S/c16-9-3-1 |
| InChI key | MVFJHEQDISFYIS-XYOKQWHBSA |
| Quality Level | 100  |
| SMILES string | S=C1N(C(=O)C(=Cc3[o]ccc |
| solubility | DMSO: 20 mg/mL, clear |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Application: | SMIFH2 was used to decipher the role of mDia2 in controlling microtubule dynamics and myofibroblast differentiation.1 |
| Biochem/physiol Actions: | SMIFH2 is an inhibitor of formin homology 2 domains. The compound is a first small molecule inhibitor of formin-mediated actin assembly that disrupts formin dependent processes from yeast to mammals. SMIFH2 may be a useful drug for identifying cellular processes dependent on formin-mediated actin assembly in a broad range of experimental systems. Formin is an actin nucleation factor. |
| Biochem/physiol Actions: | SMIFH2 is an inhibitor of formin-mediated actin assembly that disrupts formin dependent processes. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |