SB 222200

SIGMA/S5192 - ≥98% (HPLC), solid

Synonym: (S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide

CAS Number: 174635-69-9
Empirical Formula (Hill Notation): C₂₆H₂₄N₂O
Molecular Weight: 380.48
MDL Number: MFCD00944072
Linear Formula: C₂₆H₂₄N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S5192-10MG	10 mg	$202.00 1/EA		Add To Favorites
45-S5192-50MG	50 mg	$931.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow
form	solid
InChI	1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1
InChI key	MQNYRKWJSMQECI-QFIPXVFZSA-N
originator	GlaxoSmithKline
Quality Level	100
SMILES string	CC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4
solubility	DMSO: soluble ~28 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Application:	The pharmacodynamics profile of SB 222200 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.
Biochem/physiol Actions:	Non-peptide NK₃ tachykinin receptor antagonist.
Biochem/physiol Actions:	SB 222200 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.^1,2
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information:	Sold for research purposes under agreement from GlaxoSmithKline
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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