SKA-31

SIGMA/S5576 - ≥98% (HPLC)

Synonym: Naphtho[1,2-d]thiazol-2-ylamine

CAS Number: 40172-65-4
Empirical Formula (Hill Notation): C₁₁H₈N₂S
Molecular Weight: 200.26
MDL Number: MFCD00051329
Linear Formula: C₁₁H₈N₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S5576-5MG	5 mg	$122.00 1/EA		Add To Favorites
45-S5576-25MG	25 mg	$677.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	solid
InChI	1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChI key	FECQXVPRUCCUIL-UHFFFAOYSA-N
Quality Level	100
SMILES string	Nc1nc2c(ccc3ccccc23)s1
solubility	DMSO: ≥30 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.
Biochem/physiol Actions:	SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀ is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
Biochem/physiol Actions:	SKA31 is an activator of KCa2 and KCa3.1
Biochem/physiol Actions:	SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H319
Precautionary statements	P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	NONH for all modes of transport
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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