Sulfamethazine sodium salt

SIGMA/S5637 - ≥98%

Synonym: 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide

CAS Number: 1981-58-4
Empirical Formula (Hill Notation): C₁₂H₁₃N₄NaO₂S
Molecular Weight: 300.31
EC Number: 217-840-0
MDL Number: MFCD00068333
Linear Formula: C₁₂H₁₃N₄O₂SNa
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S5637-25G	25 g	$0.00 1/EA CALL FOR PRICE	Add To Favorites
45-S5637-100G	100 g	$79.20 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
assay	≥98%
color	white to off-white
form	powder
InChI	1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
InChI key	WIVZAHIZHZEEOX-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
	enzyme \| inhibits
Quality Level	200
SMILES string	[Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
solubility	H₂O: soluble 50 mg/mL
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
storage temp.	2-8°C

Application:	Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.
Biochem/physiol Actions:	Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
General description:	Chemical structure: sulfonamide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	25G,100G

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	51284910

To Order From a Quote