SYUIQ-5

SIGMA/S5826 - ≥98% (HPLC)

Synonym: N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine

CAS Number: 188630-47-9
Empirical Formula (Hill Notation): C₂₀H₂₂N₄
Molecular Weight: 318.42
MDL Number: MFCD17215940
Linear Formula: C₂₀H₂₂N₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S5826-5MG	5 mg	$311.00 1/EA		Add To Favorites
45-S5826-25MG	25 mg	$840.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22)
InChI key	CTDCVGDSVHUYMA-UHFFFAOYSA-N
Quality Level	100
SMILES string	CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13
solubility	DMSO: ≥20 mg/mL
storage temp.	2-8°C

Application:	SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.
Biochem/physiol Actions:	G-quadruplex stabilizer; induces authophagy in cancer cells.
Biochem/physiol Actions:	SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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