Synonym: N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine
CAS Number: 188630-47-9
Empirical Formula (Hill Notation): C20H22N4
Molecular Weight: 318.42
MDL Number: MFCD17215940
Linear Formula: C20H22N4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22) |
| InChI key |
CTDCVGDSVHUYMA-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13 |
| solubility |
DMSO: ≥20 mg/mL |
| storage temp. |
2-8°C |
| Application: |
SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies. |
| Biochem/physiol Actions: |
G-quadruplex stabilizer; induces authophagy in cancer cells. |
| Biochem/physiol Actions: |
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS09 |
| Signal word |
Warning |
| Hazard statements |
H400 |
| Precautionary statements |
P273 |
| Hazard Codes |
N |
| Risk Statements |
50 |
| Safety Statements |
61 |
| RIDADR |
UN 3077 9 / PGIII |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
