Sanguinarine chloride hydrate
SIGMA/S5890 - ≥98% (HPLC)
CAS Number: 5578-73-4 (anhydrous)
Empirical Formula (Hill Notation): C20H14ClNO4 · xH2O
Molecular Weight: 367.78 (anhydrous basis)
MDL Number: MFCD00012126
Linear Formula: C20H14ClNO4 · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| InChI | 1S/C20H14NO4.ClH/c1-21-8- |
| InChI key | GIZKAXHWLRYMLE-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Cl-].C[n+]1cc2c3OCOc3ccc |
| solubility | H2O: slightly soluble <0.3 mg/mL |
| methanol: 3.8 mg/mL |
| Application: | Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.9 It was tested for anti-lipase activity against Candida rugosa lipase.10 |
| Application: | Sanguinarine chloride hydrate yields clear, orange solution in methanol at 20 mg/ml. |
| Biochem/physiol Actions: | A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. |
| Biochem/physiol Actions: | A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Has antiproliferative, pro-apoptosis effects in some cancer cell lines. |
| Biochem/physiol Actions: | Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.6,7,8 |
| Packaging: | 5, 25 mg in glass insert |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |