Staurosporine from Streptomyces sp.

SIGMA/S5921 - Molecular Biology, ≥95% (HPLC)

Synonym: protein kinase c inhibitor; staurosporine; Antibiotic AM-2282

CAS Number: 62996-74-1
Empirical Formula (Hill Notation): C₂₈H₂₆N₄O₃
Molecular Weight: 466.53
MDL Number: MFCD00077402
Linear Formula: C₂₈H₂₆N₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S5921-.1MG	0.1 mg	$339.00 1/EA		Add To Favorites
45-S5921-.5MG	0.5 mg	$973.00 1/EA		Add To Favorites
45-S5921-1MG	1 mg	$1680.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
assay	≥95% (HPLC)
grade	Molecular Biology
InChI	1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
InChI key	HKSZLNNOFSGOKW-ZGQXJOJZSA-N
mode of action	enzyme \| inhibits
Quality Level	300
SMILES string	CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
storage temp.	2-8°C

Analysis Note:	Tested for inhibition of interleukin 2 production in Jurkat cells.
Application:	Staurosporine has been used as an apoptosis inducer in apoptosis assay in human colorectal cancer cell lines and to evaluate the caspase 3 and 7 activity in endothelial cell line. It has also been used as a positive control in apoptosis assay in human umbilical vein endothelial cells.
Biochem/physiol Actions:	Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Chemical structure: indol derivative
General description:	Staurosporine is an alkaloid that is obtained from Streptomyces sp. It possesses a wide range of activities such as protein kinase C inhibitor, inhibition of tumor cell proliferation, and blockage of cell cycle progression in various cells. Staurosporine is a well-known inducer of apoptosis in various cell lines. The mechanisms of staurosporine-induced apoptosis vary among different cell lines that include, mitochondrial apoptotic pathway, Bcl-2 overexpression, and caspase-independent mechanisms. It partially reverses multi-drug resistance (MDR), sensitizing cells with MDR phenotype to cytotoxic agents. Staurosporine inhibits p-glycoprotein (Pgp) phosphorylation. However, the functional significance of Pgp phosphorylation is ill-defined.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	0.1, 0.5, 1 mg in serum bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H340 - H350 - H361d - H413
Precautionary statements	P201 - P202 - P273 - P280 - P308 + P313 - P405
Hazard Codes	T
Risk Statements	45-46
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12161501

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