Somatostatin 28
SIGMA/S6135 - ≥97% (HPLC)
Synonym: Prosomatostatin
CAS Number: 73032-94-7
Empirical Formula (Hill Notation): C137H207N41O39S3
Molecular Weight: 3148.56
MDL Number: MFCD00076772
Linear Formula: C137H207N41O39S3
Product Type: Chemical
| assay | ≥97% (HPLC) |
| concentration | >70% (peptide content) |
| form | powder |
| InChI | 1S/C137H207N41O39S3/c1-69 |
| InChI key | GGYTXJNZMFRSLX-UHFFFAOYSA |
| mol wt | 3148.56 |
| Quality Level | 200  |
| SMILES string | CSCCC(NC(=O)C(C)NC(=O)C1C |
| solubility | water: 1 mg/mL, clear, colorless |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place) |
| storage temp. | −20°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P61278  |
| Amino Acid Sequence: | Ser-Ala-Asn-Ser-Asn-Pro-A |
| Application: | Somatostatin 28 has been used: • to study the effects of somatostatin in regulating hepatic growth hormone sensitivity • to study its effects on insulin-like growth factor-I receptor expression in the gills of Oncorhynchus mykiss (a teleost fish) • to assess the effects of somatostatinon GH (growth hormone)-stimulated IGF-I (insulin-like growth factor-I) expression |
| Biochem/physiol Actions: | Somatostatin action is delivered with help of five different receptor subtypes (sst1 to sst5). |
| Biochem/physiol Actions: | Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.Pituitary somatostatin receptor signaling is implicated in the inhibition of adenylyl cyclase- cyclic adenosine 3′,5′-monophosphate (cAMP)- protein kinase A (PKA) pathway. Pituitary somatostatin activity is also involved in regulation of various pathways including guanylyl cyclase and nitric oxide (NO), mitogen-activated protein kinase (MAPK) and protein kinase B (PI3K/Akt). |
| General description: | Research area: Neuroscience The SST gene is mapped to human chromosome 3q27.3. Both SST-14 and SST-28 are cyclic peptide. |
| General description: | The somatostatin gene codes for a peptide hormone containing 14 and 28 amino acid moieties. SST-14 is highly expressed in the central nervous system and peripheral organs. SST-28 is mainly expressed in enteroendocrine cells of the intestine. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |