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Sulfamethazine

SIGMA/S6256 - 99.0-101.0% (on dried basis)

Synonym: 4,6-Dimethylsulfadiazine; 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; Sulfadimethyldiazine; Sulfadimidine

CAS Number: 57-68-1
Empirical Formula (Hill Notation): C12H14N4O2S
Molecular Weight: 278.33
EC Number: 200-346-4
MDL Number: MFCD00006066
Linear Formula: C12H14N4O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S6256-25G 25 g
 $59.40
1/EA		 Add To Favorites
45-S6256-100G 100 g
 $103.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
assay 99.0-101.0% (on dried basis)
color white to off-white
form powder or crystals
InChI 1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI key ASWVTGNCAZCNNR-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
storage condition (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
storage temp. 2-8°C
Application: Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.
Biochem/physiol Actions: An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.
Biochem/physiol Actions: Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
General description: Chemical structure: sulfonamide
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging: 25G,100G
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity 99.0-101.0% (on dried basis)
Storage Temp. 2-8°C
UNSPSC 51284910

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