Monoclonal Anti-SNX6 antibody produced in mouse
SIGMA/S6324 - clone SNX6-76, ascites fluid, buffered aqueous solution
Synonym: Anti-MSTP010; Anti-Sorting Nexin 6; Anti-TFAF2; Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Product Type: Chemical
Western Blotting Whole extract of A549 cells were separated on SDS-PAGE and probed with Monoclonal Anti-SNX6 antibody produced in Mouse, Clone: SNX6-76 (Cat. No. S6324). The antibody was developed using 1:3,000 Anti-Mouse IgG (Fab specific)-Peroxidase antibody produced in Goat (Cat. No. A2304). Lanes 1. 1:2,500 antibody 2. 1:5,000 antibody
| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | SNX6-76, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgA |
| mol wt | antigen ~47 kDa |
| packaging | antibody small pack of 25 μL |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse, human, bovine, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1:2,500-1:5,000 using total extracts of A549 cells | |
| UniProt accession no. | Q9UNH7  |
| Application: | Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA. |
| Biochem/physiol Actions: | SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope . |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. |
| General description: | SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13. |
| Physical form: | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |